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Modeling human epilepsy by TALEN targeting of mouse sodium channel Scn8a
To evaluate the efficiency of TALEN technology for introducing mutations into the mouse genome we targeted Scn8a, a member of a multigene family with nine closely related paralogs. Our goal was to generate a model of early onset epileptic encephalopathy by introduction of the Scn8a missense mutation...
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| Main Authors: | , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2013
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3973152/ https://ncbi.nlm.nih.gov/pubmed/24288358 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/dvg.22731 |
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