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Modeling human epilepsy by TALEN targeting of mouse sodium channel Scn8a

To evaluate the efficiency of TALEN technology for introducing mutations into the mouse genome we targeted Scn8a, a member of a multigene family with nine closely related paralogs. Our goal was to generate a model of early onset epileptic encephalopathy by introduction of the Scn8a missense mutation...

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Autores principales: Jones, Julie M., Meisler, Miriam H.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2013
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3973152/
https://ncbi.nlm.nih.gov/pubmed/24288358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/dvg.22731
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