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Bone-specific insulin resistance disrupts whole-body glucose homeostasis via decreased osteocalcin activation
Insulin signaling in osteoblasts has been shown recently to contribute to whole-body glucose homeostasis in animals fed a normal diet; however, it is unknown whether bone contributes to the insulin resistance that develops in animals challenged by a high-fat diet (HFD). Here, we evaluated the conseq...
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| Autores principales: | , , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
American Society for Clinical Investigation
2014
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3973090/ https://ncbi.nlm.nih.gov/pubmed/24642469 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI72323 |
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