Pegylated IFN-α regulates hepatic gene expression through transient Jak/STAT activation

The use of pegylated interferon-α (pegIFN-α) has replaced unmodified recombinant IFN-α for the treatment of chronic viral hepatitis. While the superior antiviral efficacy of pegIFN-α is generally attributed to improved pharmacokinetic properties, the pharmacodynamic effects of pegIFN-α in the liver...

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Kaydedildi:
Detaylı Bibliyografya
Asıl Yazarlar: Dill, Michael T., Makowska, Zuzanna, Trincucci, Gaia, Gruber, Andreas J., Vogt, Julia E., Filipowicz, Magdalena, Calabrese, Diego, Krol, Ilona, Lau, Daryl T., Terracciano, Luigi, van Nimwegen, Erik, Roth, Volker, Heim, Markus H.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Clinical Investigation 2014
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3973080/
https://ncbi.nlm.nih.gov/pubmed/24569457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI70408
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