Autocrine IL-17A–IL-17RC neutrophil activation in fungal infections is regulated by IL-6, IL-23, RORγt and Dectin-2

Here we identified a population of bone marrow neutrophils that constitutively express RORγt and which can produce and respond to IL-17A (IL-17). IL-6, IL-23 and RORγt, but not T cells or NK cells, are required for IL-17 production in neutrophils. IL-6 and IL-23 induced IL-17RC and Dectin-2 expressi...

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Bibliografiska uppgifter
Huvudupphovsmän: Taylor, Patricia R., Roy, Sanhita, Leal, Sixto M., Sun, Yan, Howell, Scott J., Cobb, Brian A., Li, Xiaoxia, Pearlman, Eric
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2013
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3972892/
https://ncbi.nlm.nih.gov/pubmed/24362892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.2797
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