CXCR4 negatively regulates keratinocyte proliferation in IL-23-mediated psoriasiform dermatitis

CXCR4 is expressed by basal keratinocytes (KCs), but little is known about its function in inflamed skin. We crossed K14-Cre and CXCR4(flox/flox (f/f)) transgenic mice, resulting in mice with specific loss of the CXCR4 gene in K14-expressing cells (K14-CXCR4KO), including basal KCs. K14-CXCR4KO pups...

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Main Authors: Takekoshi, Tomonori, Wu, Xuesong, Mitsui, Hiroshi, Tada, Yayoi, Kao, Mandy C., Sato, Shinichi, Dwinell, Michael B., Hwang, Sam T.
Format: Artigo
Jezik:Inglês
Izdano: 2013
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3972890/
https://ncbi.nlm.nih.gov/pubmed/23528817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jid.2013.151
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