CCR6 is required for epidermal trafficking of γδ T cells in an IL-23-induced model of psoriasiform dermatitis

A subset of CCR6(+), γδ-low (GDL) T cells that express Th17 cytokines in mouse skin participates in IL-23-induced psoriasisform dermatitis. We use CCR6-deficient (KO) and wildtype (WT) mice to analyze skin trafficking patterns of GDL T cells and function-blocking mAbs to determine the role of CCR6 i...

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Detalhes bibliográficos
Main Authors: Mabuchi, Tomotaka, Singh, Tej Pratap, Takekoshi, Tomonori, Jia, Guang-fu, Wu, Xuesong, Kao, Mandy C., Weiss, Ido, Farber, Joshua M., Hwang, Sam T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3511632/
https://ncbi.nlm.nih.gov/pubmed/22895364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jid.2012.260
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