TRAF6 and p62 inhibit amyloid β-induced neuronal death through p75 neurotrophin receptor

Amyloid β (Aβ) aggregates are the primary component of senile plaques in Alzheimer disease (AD) patient’s brain. Aβ is known to bind p75 neurotrophin receptor (p75(NTR)) and mediates Aβ-induced neuronal death. Recently, we showed that NGF leads to p75(NTR) polyubiquitination, which promotes neuronal...

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Main Authors: Geetha, Thangiah, Zheng, Chen, McGregor, Wade C., White, B. Douglas, Diaz-Meco, Maria T., Moscat, Jorge, Babu, Jeganathan Ramesh
格式: Artigo
語言:Inglês
出版: 2012
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3972807/
https://ncbi.nlm.nih.gov/pubmed/23017601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuint.2012.09.005
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