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Characterization of the activation of Na+/H+ exchange in lymphocytes by phorbol esters: change in cytoplasmic pH dependence of the antiport.

Phorbol 12-myristate 13-acetate and other phorbol esters induce an intracellular alkalinization in rat thymic lymphocytes. An extracellular acidification can be recorded concomitantly. This transmembrane H+ (equivalent) flux is dependent on external Na+ and is amiloride sensitive. Phorbol esters als...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Grinstein, S, Cohen, S, Goetz, J D, Rothstein, A, Gelfand, E W
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1985
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC397275/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2983345/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.82.5.1429
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