Characteristics of the Cation Cotransporter NKCC1 in Human Brain: Alternate Transcripts, Expression in Development, and Potential Relationships to Brain Function and Schizophrenia

Early in development, GABA, an inhibitory neurotransmitter in adults, is excitatory. NKCC1 (SLC12A2) encodes one of two cation chloride cotransporters mediating the conversion of GABA from excitatory to inhibitory. Using 3′ and 5′ RACE and PCR, we verified previously characterized alternative transc...

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Auteurs principaux: Morita, Yukitaka, Callicott, Joseph H., Testa, Lauren R., Mighdoll, Michelle I., Dickinson, Dwight, Chen, Qiang, Tao, Ran, Lipska, Barbara K., Kolachana, Bhaskar, Law, Amanda J., Ye, Tianzhang, Straub, Richard E., Weinberger, Daniel R., Kleinman, Joel E., Hyde, Thomas M.
Format: Artigo
Langue:Inglês
Publié: Society for Neuroscience 2014
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Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3972720/
https://ncbi.nlm.nih.gov/pubmed/24695712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1423-13.2014
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