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Spatial Rule-Based Modeling: A Method and Its Application to the Human Mitotic Kinetochore

A common problem in the analysis of biological systems is the combinatorial explosion that emerges from the complexity of multi-protein assemblies. Conventional formalisms, like differential equations, Boolean networks and Bayesian networks, are unsuitable for dealing with the combinatorial explosio...

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Bibliographic Details
Main Authors: Ibrahim, Bashar, Henze, Richard, Gruenert, Gerd, Egbert, Matthew, Huwald, Jan, Dittrich, Peter
Format: Artigo
Language:Inglês
Published: Molecular Diversity Preservation International (MDPI) 2013
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3972674/
https://ncbi.nlm.nih.gov/pubmed/24709796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells2030506
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