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Inhibition of carbonic anhydrase augments GABA(A) receptor-mediated analgesia via a spinal mechanism of action

Peripheral nerve injury negatively influences spinal GABAergic networks via a reduction in the neuron-specific K(+)-Cl(-) cotransporter KCC2. This process has been linked to the emergence of neuropathic allodynia. In vivo pharmacological and modeling studies show that a loss of KCC2 function results...

詳細記述

保存先:
書誌詳細
主要な著者: Asiedu, Marina N., Mejia, Galo L., Hübner, Christian A., Kaila, Kai, Price, Theodore J.
フォーマット: Artigo
言語:Inglês
出版事項: 2014
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3972347/
https://ncbi.nlm.nih.gov/pubmed/24412803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jpain.2014.01.001
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