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Inhibition of carbonic anhydrase augments GABA(A) receptor-mediated analgesia via a spinal mechanism of action
Peripheral nerve injury negatively influences spinal GABAergic networks via a reduction in the neuron-specific K(+)-Cl(-) cotransporter KCC2. This process has been linked to the emergence of neuropathic allodynia. In vivo pharmacological and modeling studies show that a loss of KCC2 function results...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2014
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3972347/ https://ncbi.nlm.nih.gov/pubmed/24412803 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jpain.2014.01.001 |
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