Periostin promotes renal cyst growth and interstitial fibrosis in polycystic kidney disease

In renal cystic diseases, sustained enlargement of fluid-filled cysts is associated with severe interstitial fibrosis and progressive loss of functioning nephrons. Periostin, a matricellular protein, is highly overexpressed in cyst-lining epithelial cells of autosomal dominant polycystic disease kid...

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Hlavní autoři: Wallace, Darren P., White, Corey, Savinkova, Lyudmyla, Nivens, Emily, Reif, Gail A., Pinto, Cibele S., Raman, Archana, Parnell, Stephen C., Conway, Simon J., Fields, Timothy A.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3972302/
https://ncbi.nlm.nih.gov/pubmed/24284511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ki.2013.488
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