Overexpression of miR-125a in Myelodysplastic Syndrome CD34(+) Cells Modulates NF-κB Activation and Enhances Erythroid Differentiation Arrest

Myelodysplastic syndromes (MDS) are characterized by impaired proliferation and differentiation of hematopoietic stem cells. The participation of toll-like receptor (TLR)-mediated signaling in MDS is well documented. Increased TLR signaling leads to the constitutive activation of NF-κB, which mediat...

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Main Authors: Gañán-Gómez, Irene, Wei, Yue, Yang, Hui, Pierce, Sherry, Bueso-Ramos, Carlos, Calin, George, Boyano-Adánez, María del Carmen, García-Manero, Guillermo
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3972113/
https://ncbi.nlm.nih.gov/pubmed/24690917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0093404
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