Fetal Cyclophosphamide Exposure Induces Testicular Cancer and Reduced Spermatogenesis and Ovarian Follicle Numbers in Mice

Exposure to radiation during fetal development induces testicular germ cell tumors (TGCT) and reduces spermatogenesis in mice. However, whether DNA damaging chemotherapeutic agents elicit these effects in mice remains unclear. Among such agents, cyclophosphamide (CP) is currently used to treat breas...

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Autori principali: Comish, Paul B., Drumond, Ana Luiza, Kinnell, Hazel L., Anderson, Richard A., Matin, Angabin, Meistrich, Marvin L., Shetty, Gunapala
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2014
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3972108/
https://ncbi.nlm.nih.gov/pubmed/24691397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0093311
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