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Targeting Of Somatic Hypermutation By immunoglobulin Enhancer And Enhancer-Like Sequences
Somatic hypermutation (SH) generates point mutations within rearranged immunoglobulin (Ig) genes of activated B cells, providing genetic diversity for the affinity maturation of antibodies. SH requires the activation-induced cytidine deaminase (AID) protein and transcription of the mutation target s...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Public Library of Science
2014
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3972084/ https://ncbi.nlm.nih.gov/pubmed/24691034 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1001831 |
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