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Ultrastructural features of minute chromosomes in a methotrexate-resistant mouse 3T3 cell line

The Miller spreading procedure was applied to mouse metaphase spreads of methotrexate-resistant 3T3 cells that contain large numbers of minute chromosomes and dihydrofolate reductase genes. There is substantial variation in both size and numbers of minutes in individual cells, the smallest of which...

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Detalhes bibliográficos
Main Authors: Hamkalo, Barbara A., Farnham, Peggy J., Johnston, Randal, Schimke, Robert T.
Formato: Artigo
Idioma:Inglês
Publicado em: 1985
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC397207/
https://ncbi.nlm.nih.gov/pubmed/3856243
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