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Genetic mouse models for understanding LRRK2 biology, pathology and pre-clinical application
Missense mutations in Leucine-Rich Repeat kinase 2 (LRRK2) are the most common cause of inherited Parkinson’s disease (PD). Elucidation of LRRK2 biology and pathophysiology is central to the development of therapeutic intervention. Our group and others have developed a number of genetic mouse models...
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3972057/ https://ncbi.nlm.nih.gov/pubmed/22166428 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/S1353-8020(11)70056-6 |
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