Matrix Metalloproteinase-28 Deletion Amplifies Inflammatory and Extracellular Matrix Responses to Cardiac Aging

To determine if matrix metalloproteinase (MMP)-28 mediates cardiac aging, wild-type (WT) and MMP-28(−/−) young (7 ± 1 months, n = 9 each) and old (20 ± 2 months, n = 7 each) female mice were evaluated. MMP-28 expression in the left ventricle (LV) increased 42% in old WT mice compared to young contro...

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Hauptverfasser: Ma, Yonggang, Chiao, Ying Ann, Zhang, Jianhua, Manicone, Anne M., Jin, Yu-Fang, Lindsey, Merry L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3972008/
https://ncbi.nlm.nih.gov/pubmed/22153350
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1017/S1431927611012220
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