Cardiac aging is initiated by matrix metalloproteinase-9-mediated endothelial dysfunction

Aging is linked to increased matrix metalloproteinase-9 (MMP-9) expression and extracellular matrix turnover, as well as a decline in function of the left ventricle (LV). Previously, we demonstrated that C57BL/6J wild-type (WT) mice > 18 mo of age show impaired diastolic function, which was atten...

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Главные авторы: Yabluchanskiy, Andriy, Ma, Yonggang, Chiao, Ying Ann, Lopez, Elizabeth F., Voorhees, Andrew P., Toba, Hiroe, Hall, Michael E., Han, Hai-Chao, Lindsey, Merry L., Jin, Yu-Fang
Формат: Artigo
Язык:Inglês
Опубликовано: American Physiological Society 2014
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4024719/
https://ncbi.nlm.nih.gov/pubmed/24658018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00090.2014
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