Fibrotic extracellular matrix activates a profibrotic positive feedback loop

Pathological remodeling of the extracellular matrix (ECM) by fibroblasts leads to organ failure. Development of idiopathic pulmonary fibrosis (IPF) is characterized by a progressive fibrotic scarring in the lung that ultimately leads to asphyxiation; however, the cascade of events that promote IPF a...

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Autori principali: Parker, Matthew W., Rossi, Daniel, Peterson, Mark, Smith, Karen, Sikström, Kristina, White, Eric S., Connett, John E., Henke, Craig A., Larsson, Ola, Bitterman, Peter B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2014
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3971953/
https://ncbi.nlm.nih.gov/pubmed/24590289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI71386
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