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Fibrotic extracellular matrix activates a profibrotic positive feedback loop
Pathological remodeling of the extracellular matrix (ECM) by fibroblasts leads to organ failure. Development of idiopathic pulmonary fibrosis (IPF) is characterized by a progressive fibrotic scarring in the lung that ultimately leads to asphyxiation; however, the cascade of events that promote IPF a...
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| Main Authors: | , , , , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
American Society for Clinical Investigation
2014
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3971953/ https://ncbi.nlm.nih.gov/pubmed/24590289 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI71386 |
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