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miRNA-mediated gene silencing by translational repression followed by mRNA deadenylation and decay

miRNAs regulate gene expression through translational repression and/or mRNA deadenylation/decay. As translation, deadenylation and decay are closely linked processes, it is important to establish their ordering and thus to define the molecular mechanism of silencing. We have investigated the kineti...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Djuranovic, Sergej, Nahvi, Ali, Green, Rachel
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3971879/
https://ncbi.nlm.nih.gov/pubmed/22499947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1215691
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