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Translation efficiency is a determinant of the magnitude of miRNA-mediated repression

MicroRNAs are well known regulators of mRNA stability and translation. However, the magnitude of both translational repression and mRNA decay induced by miRNA binding varies greatly between miRNA targets. This can be the result of cis and trans factors that affect miRNA binding or action. We set out...

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Détails bibliographiques
Publié dans:Sci Rep
Auteurs principaux: Cottrell, Kyle A., Szczesny, Pawel, Djuranovic, Sergej
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2017
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5668238/
https://ncbi.nlm.nih.gov/pubmed/29097662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-13851-w
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