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Translation efficiency is a determinant of the magnitude of miRNA-mediated repression

MicroRNAs are well known regulators of mRNA stability and translation. However, the magnitude of both translational repression and mRNA decay induced by miRNA binding varies greatly between miRNA targets. This can be the result of cis and trans factors that affect miRNA binding or action. We set out...

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Библиографические подробности
Опубликовано в: :Sci Rep
Главные авторы: Cottrell, Kyle A., Szczesny, Pawel, Djuranovic, Sergej
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group UK 2017
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5668238/
https://ncbi.nlm.nih.gov/pubmed/29097662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-13851-w
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