Coupling endoplasmic reticulum stress to the cell death program: role of the ER chaperone GRP78

Alterations in Ca(2+) homeostasis and accumulation of unfolded proteins in the endoplasmic reticulum (ER) lead to an ER stress response. Prolonged ER stress may lead to cell death. Glucose-regulated protein (GRP) 78 (Bip) is an ER lumen protein whose expression is induced during ER stress. GRP78 is...

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Main Authors: Rao, Rammohan V., Peel, Alyson, Logvinova, Anna, del Rio, Gabriel, Hermel, Evan, Yokota, Takanori, Goldsmith, Paul C., Ellerby, Lisa M., Ellerby, H. Michael, Bredesen, Dale E.
Format: Artigo
Language:Inglês
Published: 2002
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3971841/
https://ncbi.nlm.nih.gov/pubmed/11943137
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