p53-mediated activation of the mitochondrial protease HtrA2/Omi prevents cell invasion

Oncogenic Ras induces cell transformation and promotes an invasive phenotype. The tumor suppressor p53 has a suppressive role in Ras-driven invasion. However, its mechanism remains poorly understood. Here we show that p53 induces activation of the mitochondrial protease high-temperature requirement...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Yamauchi, Shota, Hou, Yan Yan, Guo, Alvin Kunyao, Hirata, Hiroaki, Nakajima, Wataru, Yip, Ai Kia, Yu, Cheng-han, Harada, Ichiro, Chiam, Keng-Hwee, Sawada, Yasuhiro, Tanaka, Nobuyuki, Kawauchi, Keiko
Format: Artigo
Langue:Inglês
Publié: The Rockefeller University Press 2014
Sujets:
Research Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3971739/
https://ncbi.nlm.nih.gov/pubmed/24662565
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201309107
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