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K63 Polyubiquitination and Activation of mTOR by the p62-TRAF6 Complex in Nutrient-Activated Cells

The ability of cells to respond to changes in nutrient availability is critical for an adequate control of metabolic homeostasis. Mammalian target of rapamycin complex 1 (mTORC1) is a central complex kinase in these processes. The signaling adaptor p62 binds raptor, and integral component of the mTO...

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Detalhes bibliográficos
Main Authors: Linares, Juan F., Duran, Angeles, Yajima, Tomoko, Pasparakis, Manolis, Moscat, Jorge, Diaz-Meco, Maria T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3971544/
https://ncbi.nlm.nih.gov/pubmed/23911927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2013.06.020
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