Xanthine Oxidase Inhibition by Febuxostat Attenuates Experimental Atherosclerosis in Mice

Atherosclerosis is a chronic inflammatory disease due to lipid deposition in the arterial wall. Multiple mechanisms participate in the inflammatory process, including oxidative stress. Xanthine oxidase (XO) is a major source of reactive oxygen species (ROS) and has been linked to the pathogenesis of...

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Main Authors: Nomura, Johji, Busso, Nathalie, Ives, Annette, Matsui, Chieko, Tsujimoto, Syunsuke, Shirakura, Takashi, Tamura, Mizuho, Kobayashi, Tsunefumi, So, Alexander, Yamanaka, Yoshihiro
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2014
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3971401/
https://ncbi.nlm.nih.gov/pubmed/24686534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep04554
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