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Recent developments in biased agonism
The classic paradigm of G protein-coupled receptor (GPCR) activation was based on the understanding that agonist binding to a receptor induces or stabilizes a conformational change to an “active” conformation. In the past decade, however, it has been appreciated that ligands can induce distinct “act...
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| 主要な著者: | , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2013
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3971386/ https://ncbi.nlm.nih.gov/pubmed/24680426 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ceb.2013.10.008 |
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