Major deletions in the gene encoding the p53 tumor antigen cause lack of p53 expression in HL-60 cells.
The tumor antigen p53 is overproduced in transformed cells of various species, including man. HL-60 is an exceptional human tumor cell line that does not express this protein. Hybridization of polyadenylylated mRNA of these cells with a human p53 cDNA probe (p53-H14), which we cloned, had indicated...
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| Published in: | Proc Natl Acad Sci U S A |
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| Main Authors: | , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
National Academy of Sciences
1985
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC397132/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2858093/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.82.3.790 |
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