FUNCTIONAL EFFECTS OF POLYMORPHISMS IN THE HUMAN GENE ENCODING 11β-HSD1: A SEQUENCE VARIANT AT THE TRANSLATION START OF 11β-HSD1 ALTERS ENZYME LEVELS

Regeneration of active glucocorticoids within liver and adipose tissue by the enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) may be of pathophysiological importance in obesity and Metabolic Syndrome and is a therapeutic target in type 2 diabetes. Polymorphisms in HSD11B1, the gene encodin...

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Autori principali: Malavasi, Elise L.V., Kelly, Val, Nath, Nikita, Gambineri, Alessandra, Dakin, Rachel S., Pagotto, Uberto, Pasquali, Renato, Walker, Brian R., Chapman, Karen E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3971150/
https://ncbi.nlm.nih.gov/pubmed/19934376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2009-0663
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