The gene signature in CCAAT-enhancer-binding protein α dysfunctional acute myeloid leukemia predicts responsiveness to histone deacetylase inhibitors

C/EPBα proteins, encoded by the CCAAT-enhancer-binding protein α gene, play a crucial role in granulocytic development, and defects in this transcription factor have been reported in acute myeloid leukemia. Here, we defined the C/EBPα signature characterized by a set of genes up-regulated upon C/EBP...

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Hauptverfasser: Liss, Adam, Ooi, Chia-Huey, Zjablovskaja, Polina, Benoukraf, Touati, Radomska, Hanna S., Ju, Chen, Wu, Mengchu, Balastik, Martin, Delwel, Ruud, Brdicka, Tomas, Tan, Patrick, Tenen, Daniel G., Alberich-Jorda, Meritxell
Format: Artigo
Sprache:Inglês
Veröffentlicht: Ferrata Storti Foundation 2014
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3971080/
https://ncbi.nlm.nih.gov/pubmed/24162792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2013.093278
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