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Redesigning the procaspase-8 dimer interface for improved dimerization
Caspase-8 is a cysteine directed aspartate-specific protease that is activated at the cytosolic face of the cell membrane upon receptor ligation. A key step in the activation of caspase-8 depends on adaptor-induced dimerization of procaspase-8 monomers. Dimerization is followed by limited autoproteo...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Wiley-Blackwell
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3970895/ https://ncbi.nlm.nih.gov/pubmed/24442640 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.2426 |
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