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A bifunctional allosteric site in the dimer interface of procaspase-3
The dimer interface of caspase-3 contains a bifunctional allosteric site in which the enzyme can be activated or inactivated, depending on the context of the protein. In the mature caspase-3, the binding of allosteric inhibitors to the interface results in an order-to-disorder transition in the acti...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2011
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3166964/ https://ncbi.nlm.nih.gov/pubmed/21645959 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpc.2011.05.013 |
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