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A bifunctional allosteric site in the dimer interface of procaspase-3

The dimer interface of caspase-3 contains a bifunctional allosteric site in which the enzyme can be activated or inactivated, depending on the context of the protein. In the mature caspase-3, the binding of allosteric inhibitors to the interface results in an order-to-disorder transition in the acti...

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Main Authors: Schipper, Joshua L., MacKenzie, Sarah H., Sharma, Anil, Clark, A. Clay
Formato: Artigo
Idioma:Inglês
Publicado: 2011
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3166964/
https://ncbi.nlm.nih.gov/pubmed/21645959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpc.2011.05.013
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