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Mutations in the Procaspase-3 Dimer Interface Affect the Activity of the Zymogen()

The interface of the procaspase-3 dimer plays a critical role in zymogen maturation. We show that replacement of valine 266, the residue at the center of the procaspase-3 dimer interface, with glutamate resulted in an increase in enzyme activity of ~60-fold, representing a pseudoactivation of the pr...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Pop, Cristina, Feeney, Brett, Tripathy, Ashutosh, Clark, A. Clay
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2003
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3110659/
https://ncbi.nlm.nih.gov/pubmed/14567692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi034999p
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