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Mutations in the Procaspase-3 Dimer Interface Affect the Activity of the Zymogen()
The interface of the procaspase-3 dimer plays a critical role in zymogen maturation. We show that replacement of valine 266, the residue at the center of the procaspase-3 dimer interface, with glutamate resulted in an increase in enzyme activity of ~60-fold, representing a pseudoactivation of the pr...
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| Autors principals: | , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2003
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3110659/ https://ncbi.nlm.nih.gov/pubmed/14567692 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi034999p |
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