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Mutations in the Procaspase-3 Dimer Interface Affect the Activity of the Zymogen()

The interface of the procaspase-3 dimer plays a critical role in zymogen maturation. We show that replacement of valine 266, the residue at the center of the procaspase-3 dimer interface, with glutamate resulted in an increase in enzyme activity of ~60-fold, representing a pseudoactivation of the pr...

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Autors principals: Pop, Cristina, Feeney, Brett, Tripathy, Ashutosh, Clark, A. Clay
Format: Artigo
Idioma:Inglês
Publicat: 2003
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3110659/
https://ncbi.nlm.nih.gov/pubmed/14567692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi034999p
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