A Conformational Investigation of Propeptide Binding to the Integral Membrane Protein γ-Glutamyl Carboxylase Using Nanodisc Hydrogen Exchange Mass Spectrometry

[Image: see text] Gamma (γ)-glutamyl carboxylase (GGCX) is an integral membrane protein responsible for the post-translational catalytic conversion of select glutamic acid (Glu) residues to γ-carboxy glutamic acid (Gla) in vitamin K-dependent (VKD) proteins. Understanding the mechanism of carboxylat...

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Главные авторы: Parker, Christine H., Morgan, Christopher R., Rand, Kasper D., Engen, John R., Jorgenson, James W., Stafford, Darrel W.
Формат: Artigo
Язык:Inglês
Опубликовано: American Chemical Society 2014
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3970815/
https://ncbi.nlm.nih.gov/pubmed/24512177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi401536m
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