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Mapping the self-association domains of ataxin-1: identification of novel non overlapping motifs
The neurodegenerative disease spinocerebellar ataxia type 1 (SCA1) is caused by aggregation and misfolding of the ataxin-1 protein. While the pathology correlates with mutations that lead to expansion of a polyglutamine tract in the protein, other regions contribute to the aggregation process as als...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
PeerJ Inc.
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3970802/ https://ncbi.nlm.nih.gov/pubmed/24711972 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7717/peerj.323 |
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