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Mapping the self-association domains of ataxin-1: identification of novel non overlapping motifs

The neurodegenerative disease spinocerebellar ataxia type 1 (SCA1) is caused by aggregation and misfolding of the ataxin-1 protein. While the pathology correlates with mutations that lead to expansion of a polyglutamine tract in the protein, other regions contribute to the aggregation process as als...

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Detalhes bibliográficos
Main Authors: Menon, Rajesh P., Soong, Daniel, de Chiara, Cesira, Holt, Mark, McCormick, John E., Anilkumar, Narayana, Pastore, Annalisa
Formato: Artigo
Idioma:Inglês
Publicado em: PeerJ Inc. 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3970802/
https://ncbi.nlm.nih.gov/pubmed/24711972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7717/peerj.323
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