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Human cytomegalovirus pUL37x1-induced calcium flux activates PKCα, inducing altered cell shape and accumulation of cytoplasmic vesicles

The human cytomegalovirus immediate-early protein pUL37x1 induces the release of Ca(2+) stores from the endoplasmic reticulum into the cytosol. This release causes reorganization of the cellular actin cytoskeleton with concomitant cell rounding. Here we demonstrate that pUL37x1 activates Ca(2+)-depe...

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Bibliografische gegevens
Hoofdauteurs: Sharon-Friling, Ronit, Shenk, Thomas
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2014
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3970541/
https://ncbi.nlm.nih.gov/pubmed/24616524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1402515111
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