Protective role of miR-155 in breast cancer through RAD51 targeting impairs homologous recombination after irradiation

Cell survival after DNA damage relies on DNA repair, the abrogation of which causes genomic instability and development of cancer. However, defective DNA repair in cancer cells can be exploited for cancer therapy using DNA-damaging agents. DNA double-strand breaks are the major lethal lesions induce...

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Detalhes bibliográficos
Main Authors: Gasparini, Pierluigi, Lovat, Francesca, Fassan, Matteo, Casadei, Lucia, Cascione, Luciano, Jacob, Naduparambil K., Carasi, Stefania, Palmieri, Dario, Costinean, Stefan, Shapiro, Charles L., Huebner, Kay, Croce, Carlo M.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3970505/
https://ncbi.nlm.nih.gov/pubmed/24616504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1402604111
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