Protective role of miR-155 in breast cancer through RAD51 targeting impairs homologous recombination after irradiation

Cell survival after DNA damage relies on DNA repair, the abrogation of which causes genomic instability and development of cancer. However, defective DNA repair in cancer cells can be exploited for cancer therapy using DNA-damaging agents. DNA double-strand breaks are the major lethal lesions induce...

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Bibliografische gegevens
Hoofdauteurs: Gasparini, Pierluigi, Lovat, Francesca, Fassan, Matteo, Casadei, Lucia, Cascione, Luciano, Jacob, Naduparambil K., Carasi, Stefania, Palmieri, Dario, Costinean, Stefan, Shapiro, Charles L., Huebner, Kay, Croce, Carlo M.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2014
Onderwerpen:
Biological Sciences
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3970505/
https://ncbi.nlm.nih.gov/pubmed/24616504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1402604111
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