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Structure-Function Relationships of ErbB RTKs in the Plasma Membrane of Living Cells

We review the states of the ErbB family of receptor tyrosine kinases (RTKs), primarily the EGF receptor (EGFR, ErbB1, HER1) and the orphan receptor ErbB2 as they exist in living mammalian cells, focusing on four main aspects: (1) aggregation state and distribution in the plasma membrane; (2) conform...

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Bibliographic Details
Main Authors: Arndt-Jovin, Donna J., Botelho, Michelle G., Jovin, Thomas M.
Format: Artigo
Language:Inglês
Published: Cold Spring Harbor Laboratory Press 2014
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3970415/
https://ncbi.nlm.nih.gov/pubmed/24691959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/cshperspect.a008961
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