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Distribution of resting and ligand-bound ErbB1 and ErbB2 receptor tyrosine kinases in living cells using number and brightness analysis

Ligand-driven dimerizations of ErbB receptor subunits fulfill a fundamental role in their activation. We have used the number and brightness analysis technique to investigate the existence of preformed ligand-independent dimers and clusters and to characterize the initial steps in the activation of...

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Bibliografische gegevens
Hoofdauteurs: Nagy, Peter, Claus, Jeroen, Jovin, Thomas M., Arndt-Jovin, Donna J.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2010
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2944731/
https://ncbi.nlm.nih.gov/pubmed/20813958
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1002642107
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