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Stable liquid glucagon formulations for rescue treatment and bi-hormonal closed-loop pancreas

Small doses of glucagon given subcutaneously in the research setting by an automated system prevent most cases of hypoglycemia in persons with diabetes. However, glucagon is very unstable and cannot be kept in a portable pump. Glucagon rapidly forms amyloid fibrils, even within the first day after r...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Jackson, Melanie A., Caputo, Nicholas, Castle, Jessica R., David, Larry L., Roberts, Charles T., Ward, W. Kenneth
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3970213/
https://ncbi.nlm.nih.gov/pubmed/22972416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11892-012-0320-5
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