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Stable liquid glucagon formulations for rescue treatment and bi-hormonal closed-loop pancreas

Small doses of glucagon given subcutaneously in the research setting by an automated system prevent most cases of hypoglycemia in persons with diabetes. However, glucagon is very unstable and cannot be kept in a portable pump. Glucagon rapidly forms amyloid fibrils, even within the first day after r...

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Détails bibliographiques
Auteurs principaux: Jackson, Melanie A., Caputo, Nicholas, Castle, Jessica R., David, Larry L., Roberts, Charles T., Ward, W. Kenneth
Format: Artigo
Langue:Inglês
Publié: 2012
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3970213/
https://ncbi.nlm.nih.gov/pubmed/22972416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11892-012-0320-5
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