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Conformationally restricted analogs of somatostatin with high mu-opiate receptor specificity.

A series of cyclic, conformationally restricted analogs of somatostatin have been prepared and tested for their ability to inhibit the binding of [3H]naloxone and [D-Ala2, D-Leu5] [3H]enkephalin to rat brain membranes. The most potent analog, D-Phe-Cys-Tyr-D-Trp-Lys-Thr-Pen-Thr-NH2 where Pen is peni...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Pelton, J T, Gulya, K, Hruby, V J, Duckles, S P, Yamamura, H I
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1985
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC397007/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2857488/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.82.1.236
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