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Conformationally restricted analogs of somatostatin with high mu-opiate receptor specificity.

A series of cyclic, conformationally restricted analogs of somatostatin have been prepared and tested for their ability to inhibit the binding of [3H]naloxone and [D-Ala2, D-Leu5] [3H]enkephalin to rat brain membranes. The most potent analog, D-Phe-Cys-Tyr-D-Trp-Lys-Thr-Pen-Thr-NH2 where Pen is peni...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Pelton, J T, Gulya, K, Hruby, V J, Duckles, S P, Yamamura, H I
Format: Artigo
Sprache:Inglês
Veröffentlicht: 1985
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC397007/
https://ncbi.nlm.nih.gov/pubmed/2857488
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