PRECLINICAL SAFETY AND ACTIVITY OF RECOMBINANT VSV-IFN-B IN AN IMMUNOCOMPETENT MODEL OF SQUAMOUS CELL CARCINOMA OF THE HEAD AND NECK

BACKGROUND: VSV-IFN-β, a recombinant vesicular stomatitis virus expressing interferon-β, has demonstrated antitumor activity in vitro and in vivo. In preparation for clinical testing in human squamous cell carcinoma (SCC) of the head and neck, we conducted preclinical studies of VSV-IFN-β in syngene...

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Main Authors: Kurisetty, Vittal VS, Heiber, Joshua, Myers, Rae, Pereira, Guilherme S., Goodwin, Jarrard W., Federspiel, Mark J., Russell, Stephen J., Peng, Kah Whye, Barber, Glen, Merchan, Jaime R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3969865/
https://ncbi.nlm.nih.gov/pubmed/24115092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hed.23502
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