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Cytochrome P450 Drives a HIF-regulated Behavioral Response to Reoxygenation by C. elegans

Oxygen deprivation followed by reoxygenation causes pathological responses in many disorders, including ischemic stroke, heart attacks and reperfusion injury. Key aspects of ischemia-reperfusion can be modeled by a C. elegans behavior, the O2-ON response, which is suppressed by hypoxic preconditioni...

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Autors principals: Ma, Dengke K., Rothe, Michael, Zheng, Shu, Bhatla, Nikhil, Pender, Corinne L., Menzel, Ralph, Horvitz, H. Robert
Format: Artigo
Idioma:Inglês
Publicat: 2013
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3969381/
https://ncbi.nlm.nih.gov/pubmed/23811225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1235753
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