A Long QT Mutation Substitutes Cholesterol for Phosphatidylinositol-4,5-Bisphosphate in KCNQ1 Channel Regulation

INTRODUCTION: Phosphatidylinositol-4,5-bisphosphate (PIP(2)) is a cofactor necessary for the activity of KCNQ1 channels. Some Long QT mutations of KCNQ1, including R243H, R539W and R555C have been shown to decrease KCNQ1 interaction with PIP(2). A previous study suggested that R539W is paradoxically...

詳細記述

保存先:
書誌詳細
主要な著者: Coyan, Fabien C., Abderemane-Ali, Fayal, Amarouch, Mohamed Yassine, Piron, Julien, Mordel, Jérôme, Nicolas, Céline S., Steenman, Marja, Mérot, Jean, Marionneau, Céline, Thomas, Annick, Brasseur, Robert, Baró, Isabelle, Loussouarn, Gildas
フォーマット: Artigo
言語:Inglês
出版事項: Public Library of Science 2014
主題:
Research Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3969324/
https://ncbi.nlm.nih.gov/pubmed/24681627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0093255
タグ: タグ追加
タグなし, このレコードへの初めてのタグを付けませんか!

類似資料