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A Long QT Mutation Substitutes Cholesterol for Phosphatidylinositol-4,5-Bisphosphate in KCNQ1 Channel Regulation
INTRODUCTION: Phosphatidylinositol-4,5-bisphosphate (PIP(2)) is a cofactor necessary for the activity of KCNQ1 channels. Some Long QT mutations of KCNQ1, including R243H, R539W and R555C have been shown to decrease KCNQ1 interaction with PIP(2). A previous study suggested that R539W is paradoxically...
Αποθηκεύτηκε σε:
| Κύριοι συγγραφείς: | , , , , , , , , , , , , |
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| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
Public Library of Science
2014
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3969324/ https://ncbi.nlm.nih.gov/pubmed/24681627 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0093255 |
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