Bacterial expression of human kynurenine 3-monooxygenase: Solubility, activity, purification()

Kynurenine 3-monooxygenase (KMO) is an enzyme central to the kynurenine pathway of tryptophan metabolism. KMO has been implicated as a therapeutic target in several disease states, including Huntington’s disease. Recombinant human KMO protein production is challenging due to the presence of transmem...

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Bibliografiske detaljer
Main Authors: Wilson, K., Mole, D.J., Binnie, M., Homer, N.Z.M., Zheng, X., Yard, B.A., Iredale, J.P., Auer, M., Webster, S.P.
Format: Artigo
Sprog:Inglês
Udgivet: Academic Press 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3969302/
https://ncbi.nlm.nih.gov/pubmed/24316190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pep.2013.11.015
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